Anti-AIDS agents .29. Anti-HIV activity of modified podophyllotoxin derivatives

被引：23

作者：

Lee, CTL

Lin, VCK

Zhang, SX

Zhu, XK

VanVliet, D

Hu, H

Beers, SA

Wang, ZQ

Cosentino, LM

MorrisNatschke, SL

Lee, KH

机构：

[1] UNIV N CAROLINA,SCH PHARM,DIV MED CHEM & NAT PROD,NAT PROD LAB,CHAPEL HILL,NC 27599

[2] BIOTECH RES LABS INC,ROCKVILLE,MD 20850

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1997年 / 7卷 / 22期

关键词：

D O I：

10.1016/S0960-894X(97)10108-1

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Podophyllotoxin derivatives containing structural modifications at C-4 and in the methylenedioxy A-ring, lactone D-ring, and phenyl E-ring have been tested for inhibition of HIV replication. The four most promising compounds (6, 7, 8, and 19), with the methylenedioxy A-ring opened and methylated and the 4'-position demethylated, had EC50's less than 0.001 mu M and therapeutic indices greater than 120. (C) 1997 Elsevier Science Ltd.

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页码：2897 / 2902

页数：6

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