Transforming growth factor-β1 increases the expression of lectin-like oxidized low-density lipoprotein receptor-1

被引:99
作者
Minami, M
Kume, N
Kataoka, H
Morimoto, M
Hayashida, K
Sawamura, T
Masaki, T
Kita, T
机构
[1] Kyoto Univ, Grad Sch Med, Dept Geriatr Med, Sakyo Ku, Kyoto 6068507, Japan
[2] Natl Cardiovasc Ctr, Res Inst, Osaka 5658565, Japan
关键词
atherosclerosis; LOX-1; oxidized low-density lipoprotein; TGF-beta(1); vascular remodeling;
D O I
10.1006/bbrc.2000.2778
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Lectin-like oxidized low-density lipoprotein (Ox-LDL) receptor-1 (LOX-1) is a novel cell-surface receptor for Ox-LDL, which can be expressed by vascular endothelial cells, smooth muscle cells, and macrophages. On the other hand, transforming growth factor (TGF)-beta(1), which plays crucial roles in vascular remodeling and the pathogenesis of atherosclerosis, has been shown to inhibit expression of class A scavenger receptors and CD36 in macrophages. Here we provide the evidence that TGF-beta(1) (0.1-10 ng/mL) induces LOX-1 protein and mRNA expression in both bovine aortic endothelial cells and smooth muscle cells in a dose- and time-dependent fashion, probably at the transcriptional level. TGF-beta(1) also upregulates LOX-1 mRNA expression in murine peritoneal macrophages. Thus TGF-beta(1) can highly induce LOX-1 expression in vascular endothelial cells, smooth muscle cells, and macrophages, suggesting that TGF-beta(1) appears one of the key regulators that modulates expression of scavenger receptors. (C) 2000 Academic Press.
引用
收藏
页码:357 / 361
页数:5
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