Methadone reincarnated: Novel clinical applications with related concerns

被引：88

作者：

Fishman, SM ^{[1
]}

Wilsey, B

Mahajan, G

Molina, P

机构：

[1] Univ Calif Davis, Div Pain Med, Sacramento, CA 95817 USA

[2] Univ Calif Davis, Dept Anesthesiol & Pain Med, Sacramento, CA 95817 USA

[3] Univ Calif Davis, No Calif Vet Adm Pain Clin, Sacramento, CA 95817 USA

来源：

PAIN MEDICINE | 2002年 / 3卷 / 04期

关键词：

methadone; analgesia; pain; tolerance; opioid; rotation; neuropathic; drug interactions;

D O I：

10.1046/j.1526-4637.2002.02047.x

中图分类号：

R614 [麻醉学];

学科分类号：

100217 ;

摘要：

Methadone has numerous advantages as an analgesic, which have supported its recent increase in use. However, methadone also has a pharmacological profile as an opioid that differentiates it from other, better known or more widely used opioids. It also has unusual pharmacodynamics, pharmacokinetics, and metabolism that must be considered for safe use of methadone as an analgesic. This review looks at the history of methadone use as an analgesic and its properties that distinguish it as an unusual, and potentially, unstable opioid.

引用

页码：339 / 348

页数：10

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