Substituent effect of camphor sulfonamide ligand on the asymmetric addition of diethylzinc to aldehyde

被引：7

作者：

Hui, Ai-Ling

Zhang, Jin-Tang

Wang, Zhi-Yong ^{[1
]}

机构：

[1] Univ Sci & Technol China, Hefei Natl Lab Phys Sch Microscale, Hefei 230026, Peoples R China

[2] Univ Sci & Technol China, Dept Chem, Hefei 230026, Peoples R China

来源：

ARKIVOC | 2006年

关键词：

camphor sulfonamide; diethylzinc; aldehyde; substitution; enantioselective;

D O I：

10.3998/ark.5550190.0007.d05

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A variety of camphor sulfonamide ligands were synthesized and employed in the addition of diethylzinc to aldehydes. The influences of substitution patterns, electronic property, reaction substrates, reaction solvents and temperature were studied. After optimization, the best reaction condition was determined and applied to this addition reaction, giving the corresponding products in high yields with up to 83% ee.

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收藏

页码：41 / 56

页数：16

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