Hyperbaric oxygenation induced tolerance against focal cerebral ischemia in mice is strain dependent

被引：98

作者：

Prass, K

Wiegand, F

Schumann, P

Ahrens, M

Kapinya, K

Harms, C

Liao, WJ

Trendelenburg, G

Gertz, K

Moskowitz, MA

Knapp, F

Victorov, IV

Megow, D

Dirnagl, U ^{[1
]}

机构：

[1] Humboldt Univ, Dept Neurol, Berlin, Germany

[2] Univ Essen Gesamthsch, Dept Neurol, D-4300 Essen, Germany

[3] Univ Caen, CNRS, UMR 6551, F-14032 Caen, France

[4] Russian Acad Med Sci, Brain Res Inst, Moscow, Russia

[5] Harvard Univ, Sch Med, Massachusetts Gen Hosp, Stroke Res Lab, Charlestown, MA USA

来源：

BRAIN RESEARCH | 2000年 / 871卷 / 01期

关键词：

C57BL/6; mouse; oxygen free radical; preconditioning; SV129; stroke;

D O I：

10.1016/S0006-8993(00)02264-2

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

SV129 or C57BL/6 mice were exposed to hyperbaric oxygenation (HBO, 5 days, 1 h every day, 100% O-2 at 3 atm absolute). One day after the 5th HBO session focal cerebral ischemia was induced. In SV129 mice, HBO induced tolerance against permanent focal cerebral ischemia (n = 42, mean infarct volume reduction 27%, P = 0.001), but not against transient (30 or 60 min) focal cerebral ischemia. In the C57BL/6 strain of mice, HBO did not induce tolerance against focal cerebral ischemia, even when the duration of ischemia or the HBO protocol were modified. For the first time we demonstrate that HBO can induce tolerance to focal cerebral ischemia, but this effect is strain dependent. (C) 2000 Elsevier Science B.V. All rights reserved.

引用

页码：146 / 150

页数：5