Stoichiometric noncovalent interaction in molecular imprinting

被引:132
作者
Wulff, G [1 ]
Knorr, K [1 ]
机构
[1] Univ Dusseldorf, Inst Organ Chem & Macromol Chem, D-40225 Dusseldorf, Germany
关键词
association constants; functional monomers; molecular imprinting; stoichiometric noncovalent interaction;
D O I
10.1023/A:1021585518592
中图分类号
Q5 [生物化学];
学科分类号
071010 ; 081704 ;
摘要
In this review article the function of the binding site monomers in the molecular imprinting procedure is discussed. Especially, new developments towards stoichiometric noncovalent interactions are highlighted. In stoichiometric noncovalent interactions template and binding site monomer in an 1:1 molar ratio are nearly completely bound to each other. This is only possible if the association constants are considerably high (K-ass > 900 M-1). Using this type of interaction in molecular imprinting no excess of binding sites is necessary and binding sites are only located inside the imprinted cavity. Since all cavities can be reloaded these polymers show high capacity (e.g., for preparative application) and are especially suited for the synthesis of catalytically active imprinted polymers. Discussed are binding site interactions based on amidines (and guanidines), multiple hydrogen bonding, charge-transfer interactions, and host-guest inclusion. The systematic investigation of the underlying binding reaction is described in detail. With low-molecular weight model substances the thermodynamics of the association can be conveniently investigated, e.g., by NMR spectroscopy.
引用
收藏
页码:257 / 276
页数:20
相关论文
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