GA2LEN skin test study III: Minimum battery of test inhalent allergens needed in epidemiological studies in patients

被引：90

作者：

Bousquet, P. -J. ^{[1
]}

Burbach, G. ^{[2
]}

Heinzerling, L. M. ^{[2
]}

Edenharter, G. ^{[2
]}

Bachert, C. ^{[3
]}

Bindslev-Jensen, C. ^{[4
]}

Bonini, S. ^{[5
]}

Bousquet-Rouanet, L. ^{[6
]}

Demoly, P. ^{[6
]}

Bresciani, M. ^{[5
]}

Bruno, A. ^{[7
]}

Gjomarkaj, M. ^{[7
]}

Canonica, G. W. ^{[8
]}

Darsow, U. ^{[9
,10
]}

Durham, S. ^{[11
]}

Fokkens, W. J. ^{[12
]}

Giavi, S. ^{[13
]}

Gramiccioni, C. ^{[5
]}

Papadopoulos, N. G. ^{[13
]}

Haahtela, T. ^{[14
]}

Kowalski, M. L. ^{[15
]}

Magyar, P. ^{[16
]}

Murakozi, G. ^{[5
]}

Orosz, M. ^{[17
]}

Roehnelt, C. ^{[2
]}

Stingl, G. ^{[17
]}

Todo-Bom, A. ^{[18
]}

von Mutius, E. ^{[19
]}

Wiesner, A. ^{[20
]}

Woehrl, S. ^{[17
]}

Bousquet, J. ^{[6
]}

Zuberbier, T. ^{[2
]}

机构：

[1] Grp Hosp Univ Caremeau, Dept Biostat Epidemiol Clin Sante Publ & Informat, Nimes, France

[2] Charite, Dept Dermatol & Allergy, D-13353 Berlin, Germany

[3] Ghent Univ Hosp, Dept Otorhinolaryngol, B-9000 Ghent, Belgium

[4] Odense Univ Hosp, Allergy Ctr, DK-5000 Odense, Denmark

[5] CNR, Rome, Italy

[6] Univ Hosp, Montpellier, France

[7] CNR, Palermo, Italy

[8] Univ Genoa, Genoa, Italy

[9] Tech Univ Munich, Dept Dermatol & Allergy, Munich, Germany

[10] Tech Univ Munich, Div Environm Dermatol & Allergy, GSF, Munich, Germany

[11] Royal Brompton Hosp, Dept Resp Med, London SW3 6LY, England

[12] Univ Amsterdam, Acad Med Ctr, Dept Otorhinolaryngol, NL-1105 AZ Amsterdam, Netherlands

[13] Univ Athens, Dept Allergy, Pediat Clin 2, Athens 11528, Greece

[14] Univ Helsinki, Cent Hosp, Helsinki, Finland

[15] Med Univ Lodz, Dept Allergy & Clin Immunol, Lodz, Poland

[16] Semmelweis Univ, H-1085 Budapest, Hungary

[17] Med Univ Vienna, Dept Dermatol, Vienna, Austria

[18] Univ Coimbra, Coimbra, Portugal

[19] Univ Munich, Munich, Germany

[20] Childrens Univ Hosp, Zurich, Switzerland

来源：

ALLERGY | 2009年 / 64卷 / 11期

关键词：

allergen; GA2LEN; sensitization; skin prick test; RESPIRATORY HEALTH SURVEY; INHALANT ALLERGENS; SENSITIZATION; STANDARDIZATION; GA(2)LEN; EUROPE;

D O I：

10.1111/j.1398-9995.2009.02169.x

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

Background: The number of allergens to be tested in order to identify sensitized patients is important in order to have the most cost-effective approach in epidemiological studies. Objective: To define the minimal number and the type of skin prick test (SPT) allergens required to identify a patient as sensitized using results of the new Pan-European GA2LEN skin prick test study. Method: In a large Pan-European multicenter (17 centers in 14 countries) patient based study, a standardized panel of 18 allergens has been prick tested using a standardized procedure. Conditional approach allowed to determine the allergens selection. Result: Among the 3034 patients involved, 1996 (68.2%) were sensitized to at least one allergen. Overall, eight allergens (grass pollen, Dermatophagoides pteronyssinus, birch pollen, cat dander, Artemisia, olive pollen, Blatella and Alternaria) allowed to identified more than 95% of sensitized subjects. However, differences were observed between countries, two allergens being sufficient for Switzerland (grass pollen and cat dander) as opposed to nine for France (grass pollen, Dermatophagoides pteronyssinus, olive pollen, cat dander, Blatella, cypress, dog dander, alder and [Artemisia or Alternaria]). According to country, up to 13 allergens were needed to identify all sensitized subjects. Conclusion: Eight to ten allergens allowed the identification of the majority of sensitized subjects. For clinical care of individual patients, the whole battery of 18 allergens is needed to appropriately assess sensitization across Europe.

引用

页码：1656 / 1662

页数：7

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