AAA proteases in mitochondria: diverse functions of membrane-bound proteolytic machines

被引：70

作者：

Tatsuta, Takashi ^{[1
]}

Langer, Thomas ^{[1
,2
]}

机构：

[1] Univ Cologne, Inst Genet, Ctr Mol Med CMMC, Cologne Excellence Cluster Cellular Stress Respon, D-50674 Cologne, Germany

[2] Max Planck Inst Biol Aging, D-50931 Cologne, Germany

来源：

RESEARCH IN MICROBIOLOGY | 2009年 / 160卷 / 09期

基金：

欧洲研究理事会;

关键词：

AAA plus proteins; ATP-dependent proteases; Mitochondria; Mitochondrial fusion; Neurodegeneration; Quality control of proteins; HEREDITARY SPASTIC PARAPLEGIA; CHAPERONE-LIKE ACTIVITY; SACCHAROMYCES-CEREVISIAE; PROTEIN-DEGRADATION; CRISTAE MORPHOGENESIS; INTERMEMBRANE SPACE; SUBUNIT COMPOSITION; CELL-PROLIFERATION; RESPIRATORY-CHAIN; ATP HYDROLYSIS;

D O I：

10.1016/j.resmic.2009.09.005

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

FtsH/AAA proteases comprise a distinct family of membrane-bound, ATP-dependent proteases present in eubacteria and eukaryotic cells, where they are confined to mitochondria and chloroplasts. Here, we will summarize versatile functions of AAA proteases within mitochondria, which ensure mitochondrial integrity and cell survival, acting both as quality control and processing enzymes. (C) 2009 Elsevier Masson SAS. All rights reserved.

引用

页码：711 / 717

页数：7

共 51 条

[21] Oma1, a novel membrane-bound metallopeptidase in mitochondria with activities overlapping with the m-AAA protease
Käser, M
Kambacheld, M
Kisters-Woike, B
Langer, T
[J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2003, 278 (47) : 46414 - 46423
[22] A protease complex in the Escherichia coli plasma membrane: HflKC (HflA) forms a complex with FtsH (HflB), regulating its proteolytic activity against SecY
Kihara, A
Akiyama, Y
Ito, K
[J]. EMBO JOURNAL, 1996, 15 (22) : 6122 - 6131
[23] Different pathways for protein degradation by the FtsH/HflKC membrane-embedded protease complex: An implication from the interference by a mutant form of a new substrate protein, YccA
Kihara, A
Akiyama, Y
Ito, K
[J]. JOURNAL OF MOLECULAR BIOLOGY, 1998, 279 (01) : 175 - 188
[24] Adapting the machine: adaptor proteins for Hsp100/Clp and AAA plus proteases
Kirstein, Janine
Moliere, Noel
Dougan, David A.
Turgay, Kuersad
[J]. NATURE REVIEWS MICROBIOLOGY, 2009, 7 (08) : 589 - 599
[25] Variable and tissue-specific subunit composition of mitochondrial m-AAA protease complexes linked to hereditary spastic paraplegia
Koppen, Mirko
Metodiev, Metodi D.
Casari, Giorgio
Rugarli, Elena I.
Langer, Thomas
[J]. MOLECULAR AND CELLULAR BIOLOGY, 2007, 27 (02) : 758 - 767
[26] Autocatalytic Processing of m-AAA Protease Subunits in Mitochondria
Koppen, Mirko
Bonn, Florian
Ehses, Sarah
Langer, Thomas
[J]. MOLECULAR BIOLOGY OF THE CELL, 2009, 20 (19) : 4216 - 4224
[27] Absence of the mitochondrial AAA protease Yme1p restores F0-ATPase subunit accumulation in an oxa1 deletion mutant of Saccharomyces cerevisiae
Lemaire, C
Hamel, P
Velours, J
Dujardin, G
[J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2000, 275 (31) : 23471 - 23475
[28] AAA proteases with catalytic sites on opposite membrane surfaces comprise a proteolytic system for the ATP-dependent degradation of inner membrane proteins in mitochondria
Leonhard, K
Herrmann, JM
Stuart, RA
Mannhaupt, G
Neupert, W
Langer, T
[J]. EMBO JOURNAL, 1996, 15 (16) : 4218 - 4229
[29] Membrane protein degradation by AAA proteases in mitochondria: Extraction of substrates from either membrane surface
Leonhard, K
Guiard, B
Pellecchia, G
Tzagoloff, A
Neupert, W
Langer, T
[J]. MOLECULAR CELL, 2000, 5 (04) : 629 - 638
[30] Chaperone-like activity of the AAA domain of the yeast Yme1 AAA protease
Leonhard, K
Stiegler, A
Neupert, W
Langer, T
[J]. NATURE, 1999, 398 (6725) : 348 - 351

← 1 2 3 4 5 6 →