Fluorescent bioprobes for visualization of puromycin-sensitive aminopeptidase in living cells

被引：18

作者：

Kakuta, H ^{[1
]}

Koiso, Y ^{[1
]}

Nagasawa, K ^{[1
]}

Hashimoto, Y ^{[1
]}

机构：

[1] Univ Tokyo, Inst Mol & Cellular Biosci, Bunkyo Ku, Tokyo 1130032, Japan

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2003年 / 13卷 / 01期

关键词：

D O I：

10.1016/S0960-894X(02)00845-4

中图分类号：

R914 [药物化学];

学科分类号：

100701 [药物化学];

摘要：

Non-peptide, small-molecular, non-competitive inhibitors of puromycin-sensitive aminopeptidase (PSA), that is, 3-(2,6-diethylphenyl)-2,4(1H,3 H)-quinazolinedione (PAQ-22, 3) and its 1N-methyl analogue (MPAQ-22 4), were structurally modified to afford fluorescent bioprobes, ANTAQ (5) and DAMPAQ-22 (6). The cellular localization of PSA could be visualized by the use of these fluorescent bioprobes. (C) 2002 Elsevier Science Ltd. All rights reserved.

引用

页码：83 / 86

页数：4

共 20 条

[1]

Human puromycin-sensitive aminopeptidase:: cloning of 3′ UTR, evidence for a polymorphism at aa 140 and refined chromosomal localization to 17q21 [J].