Nickel inhibits binding of alpha(2)-macroglobulin-methylamine to the low-density lipoprotein receptor-related protein/alpha(2)-macroglobulin receptor but not the alpha(2)-macroglobulin signaling receptor

被引：22

作者：

Odom, AR ^{[1
]}

Misra, UK ^{[1
]}

Pizzo, SV ^{[1
]}

机构：

[1] DUKE UNIV,MED CTR,DEPT PATHOL,DURHAM,NC 27710

来源：

BIOCHEMISTRY | 1997年 / 36卷 / 41期

关键词：

D O I：

10.1021/bi970806k

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A previous study demonstrated that activated alpha/(2)-macroglobulin (alpha/M-2*) binding to the low-density receptor-related protein/alpha 2 macroglobulin receptor (LRP/alpha(2)MR) is blocked by Ni2+ [Hussain, M. M,, et al. (1995) Biochemistry 34, 16074-16081], We now report that the effect of Ni2+ is on a region of the alpha(2)M molecule upstream of the carboxyl terminal receptor recognition domain. This observation is consistent with previous observations from this laboratory suggesting that alpha(2)M* binding to LRP/alpha(2)MR involves a region of the alpha(2)M molecule immediately upstream of the receptor recognition domain [Enghild, J, J., et al. (1989) Biochemistry 28, 1406-1412]. We further demonstrate that Ni2+ has no effect on the binding of alpha(2)M* or a cloned and expressed receptor binding fragment (RBF) to the recently described alpha(2)M Signaling receptor as assessed by direct binding and signal transduction studie.

引用

收藏

页码：12395 / 12399

页数：5

相关论文

共 34 条

[11]

GROBMYER SR, 1993, J BIOL CHEM, V268, P13291

[12] Identification of residues in alpha-macroglobulins involved in activation of the alpha(2)-macroglobulin signaling receptor [J].

Howard, GC ;

DeCamp, DL ;

Misra, UK ;

Pizzo, SV .

BIOCHIMICA ET BIOPHYSICA ACTA-PROTEIN STRUCTURE AND MOLECULAR ENZYMOLOGY, 1996, 1297 (02) :111-114

[13] Characterization of alpha(2)-macroglobulin binding to human trabecular meshwork cells: Presence of the alpha(2)-macroglobulin signaling receptor [J].

Howard, GC ;

Roberts, BC ;

Epstein, DL ;

Pizzo, SV .

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 1996, 333 (01) :19-26

[14] Selective mutations in cloned and expressed alpha-macroglobulin receptor binding fragment alter binding to either the alpha(2)-macroglobulin signaling receptor or the low density lipoprotein receptor-related protein/alpha(2)-macroglobulin receptor [J].

Howard, GC ;

Yamaguchi, Y ;

Misra, UK ;

Gawdi, G ;

Nelsen, A ;

DeCamp, DL ;

Pizzo, SV .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1996, 271 (24) :14105-14111

[15] Altered interaction of cis-dichlorodiammineplatinum(II)-modified alpha(2)-macrooglobulin (alpha(2)M) with the low density lipoprotein receptor-related protein/alpha(2)M receptor but not the alpha(2)M signaling receptor - Evidence for interference with receptor dissociation and recycling [J].

Howard, GC ;

Misra, UK ;

DeCamp, DL ;

Pizzo, SV .

JOURNAL OF CLINICAL INVESTIGATION, 1996, 97 (05) :1193-1203

[16] Nickel is a specific inhibitor for the binding of activated alpha(2)-macroglobulin to the low density lipoprotein receptor-related protein alpha(2)-macroglobulin receptor [J].

Hussain, MM ;

Kancha, RK ;

Tulenko, TN .

BIOCHEMISTRY, 1995, 34 (49) :16074-16081

[17]

IMBER MJ, 1981, J BIOL CHEM, V256, P8134

[18]

ISAACS IJ, 1988, J BIOL CHEM, V263, P6709

[19] STRUCTURES AND FUNCTIONS OF MULTILIGAND LIPOPROTEIN RECEPTORS - MACROPHAGE SCAVENGER RECEPTORS AND LDL RECEPTOR-RELATED PROTEIN (LRP) [J].

KRIEGER, M ;

HERZ, J .

ANNUAL REVIEW OF BIOCHEMISTRY, 1994, 63 :601-637

[20] EVIDENCE THAT THE NEWLY CLONED LOW-DENSITY-LIPOPROTEIN RECEPTOR RELATED PROTEIN (LRP) IS THE ALPHA-2-MACROGLOBULIN RECEPTOR [J].

KRISTENSEN, T ;

MOESTRUP, SK ;

GLIEMANN, J ;

BENDTSEN, L ;

SAND, O ;

SOTTRUPJENSEN, L .

FEBS LETTERS, 1990, 276 (1-2) :151-155

← 1 2 3 4 →