Selective inhibition of the duck hepatitis B virus by a new class of tetraazamacrocycles

被引：12

作者：

Hantz, O ^{[1
]}

Borel, C ^{[1
]}

Trabaud, C ^{[1
]}

Zoulim, F ^{[1
]}

Dessolin, J ^{[1
]}

Camplo, M ^{[1
]}

Vlieghe, P ^{[1
]}

Bouygues, M ^{[1
]}

Trepo, C ^{[1
]}

Kraus, JL ^{[1
]}

机构：

[1] INSERM,U322,UNITE RECH RETROVIRUS & MALAD ASSOCIEES,F-13223 MARSEILLE,FRANCE

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 1997年 / 41卷 / 11期

关键词：

D O I：

10.1128/AAC.41.11.2579

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The antiviral activity of a new class of N,N,N',N '',N'''-pentakis (omega-aminoalkyl) tetraazamacrocycles was evaluated in primary duck hepatocyte cultures infected with the duck hepatitis B virus (DHBV). Three of the four tested compounds were able to selectively inhibit DHBV replication by acting at an early step of the hepadnavirus infection but were associated with significant toxicity.

引用

页码：2579 / 2581

页数：3

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