Pharmacogenomics of organic anion-transporting polypeptides (OATP)

被引：78

作者：

Tirona, RG

Kim, RB

机构：

[1] Vanderbilt Univ, Sch Med, Dept Med, Div Clin Pharmacol, Nashville, TN 37232 USA

[2] Vanderbilt Univ, Sch Med, Dept Pharmacol, Div Clin Pharmacol, Nashville, TN 37232 USA

来源：

ADVANCED DRUG DELIVERY REVIEWS | 2002年 / 54卷 / 10期

关键词：

drug transporter; single nucleotide polymorphism; drug disposition;

D O I：

10.1016/S0169-409X(02)00077-7

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The organic anion-transporting polypeptides (OATP) represent a family of proteins responsible for the membrane transport of a large number of endogenous and xenobiotic compounds with diverse chemical characteristics. OATP's are expressed in liver, kidney, brain and intestine suggesting that they may play a critical role in drug disposition. Naturally occurring polymorphisms in OATPs are currently being identified and for some, in vitro transport activities have been characterized. In this article, we review the molecular, biochemical and pharmacological aspects of known human OATPs including the presence and functional relevance of genetic polymorphisms. (C) 2002 Elsevier Science B.V. All rights reserved.

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页码：1343 / 1352

页数：10

相关论文

共 56 条

[1] LST-2, a human liver-specific organic anion transporter, determines methotrexate sensitivity in gastrointestinal cancers [J].

Abe, T ;

Unno, M ;

Onogawa, T ;

Tokui, T ;

Kondo, TN ;

Nakagomi, R ;

Adachi, H ;

Fujiwara, K ;

Okabe, M ;

Suzuki, T ;

Nunoki, K ;

Sato, E ;

Kakyo, M ;

Nishio, T ;

Sugita, J ;

Asano, N ;

Tanemoto, M ;

Seki, M ;

Date, F ;

Ono, K ;

Kondo, Y ;

Shiiba, K ;

Suzuki, M ;

Ohtani, H ;

Shimosegawa, T ;

Iinuma, K ;

Nagura, H ;

Ito, S ;

Matsuno, S .

GASTROENTEROLOGY, 2001, 120 (07) :1689-1699

[2] Identification of a novel gene family encoding human liver-specific organic anion transporter LST-1 [J].

Abe, T ;

Kakyo, M ;

Tokui, T ;

Nakagomi, R ;

Nishio, T ;

Nakai, D ;

Nomura, H ;

Unno, M ;

Suzuki, M ;

Naitoh, T ;

Matsuno, S ;

Yawo, H .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1999, 274 (24) :17159-17163

[3] The choroid plexus epithelium is the site of the organic anion transport protein in the brain [J].

Angeletti, RH ;

Novikoff, PM ;

Juvvadi, SR ;

Fritschy, JM ;

Meier, PJ ;

Wolkoff, AW .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1997, 94 (01) :283-286

[4]

BERGWERK AJ, 2000, AM J PHYSIOL, V271, pG231

[5] Multispecific amphipathic substrate transport by an organic anion transporter of human liver [J].

Bossuyt, X ;

Muller, M ;

Meier, PJ .

JOURNAL OF HEPATOLOGY, 1996, 25 (05) :733-738

[6] An evolutionarily ancient Oatp: insights into conserved functional domains of these proteins [J].

Cai, SY ;

Wang, W ;

Soroka, CJ ;

Ballatori, N ;

Boyer, JL .

AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY, 2002, 282 (04) :G702-G710

[7] Bile acid transport and regulating functions in the human biliary epithelium [J].

Chignard, N ;

Mergey, M ;

Veissière, D ;

Parc, R ;

Capeau, J ;

Poupon, R ;

Paul, A ;

Housset, C .

HEPATOLOGY, 2001, 33 (03) :496-503

[8] Hepatic uptake of bilirubin and its conjugates by the human organic anion transporter SLC21A6 [J].

Cui, Y ;

König, J ;

Leier, I ;

Buchholz, U ;

Keppler, D .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2001, 276 (13) :9626-9630

[9] Vectorial transport by double-transfected cells expressing the human uptake transporter SLC21A8 and the apical export pump ABCC2 [J].

Cui, YH ;

König, J ;

Keppler, D .

MOLECULAR PHARMACOLOGY, 2001, 60 (05) :934-943

[10]

Cvetkovic M, 1999, DRUG METAB DISPOS, V27, P866

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