Pharmacogenomics of organic anion-transporting polypeptides (OATP)

被引：78

作者：

Tirona, RG

Kim, RB

机构：

[1] Vanderbilt Univ, Sch Med, Dept Med, Div Clin Pharmacol, Nashville, TN 37232 USA

[2] Vanderbilt Univ, Sch Med, Dept Pharmacol, Div Clin Pharmacol, Nashville, TN 37232 USA

来源：

ADVANCED DRUG DELIVERY REVIEWS | 2002年 / 54卷 / 10期

关键词：

drug transporter; single nucleotide polymorphism; drug disposition;

D O I：

10.1016/S0169-409X(02)00077-7

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The organic anion-transporting polypeptides (OATP) represent a family of proteins responsible for the membrane transport of a large number of endogenous and xenobiotic compounds with diverse chemical characteristics. OATP's are expressed in liver, kidney, brain and intestine suggesting that they may play a critical role in drug disposition. Naturally occurring polymorphisms in OATPs are currently being identified and for some, in vitro transport activities have been characterized. In this article, we review the molecular, biochemical and pharmacological aspects of known human OATPs including the presence and functional relevance of genetic polymorphisms. (C) 2002 Elsevier Science B.V. All rights reserved.

引用

页码：1343 / 1352

页数：10

共 56 条

[51] Polymorphisms in OATP-C -: Identification of multiple allelic variants associated with altered transport activity among European- and African-Americans [J].