First total synthesis of topopyrone C

被引：22

作者：

Gattinoni, Sonia ^{[1
]}

Merlini, Lucio ^{[1
]}

Dallavalle, Sabrina ^{[1
]}

机构：

[1] Univ Milan, Dipartimento Sci Mol Agroalimentari, I-20133 Milan, Italy

来源：

TETRAHEDRON LETTERS | 2007年 / 48卷 / 06期

关键词：

topopyrone C; synthesis; anthraquinone; topoisomerase; Marschalk reaction;

D O I：

10.1016/j.tetlet.2006.11.164

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The first synthesis of topopyrone C, a natural compound and inhibitor of Topoisomerase 1, has been carried out by Mars-chalk alkylation of 1-hydroxy-3,6,8-trimethoxyanthraquinone, followed by a Baker-Venkataraman chain elongation and an acidcatalyzed cyclization for the construction of the pyrone ring. (c) 2006 Elsevier Ltd. All rights reserved.

引用

页码：1049 / 1051

页数：3

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