Cannabinoids in the treatment of cancer

被引：92

作者：

Alexander, Amy ^{[1
]}

Smith, Paul F. ^{[1
]}

Rosengren, Rhonda J. ^{[1
]}

机构：

[1] Univ Otago, Dept Pharmacol & Toxicol, Dunedin, New Zealand

来源：

CANCER LETTERS | 2009年 / 285卷 / 01期

关键词：

Cannabinoids; JWH-133; CB1; CB2; MAPK; ACTIVATED PROTEIN-KINASE; NECROSIS-FACTOR-ALPHA; SELECTIVE ANTAGONIST; RECEPTOR; STIMULATION; INVOLVEMENT; GROWTH; CB1; CELLS; PROLIFERATION;

D O I：

10.1016/j.canlet.2009.04.005

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Cannabinoids, the active components of the hemp plant Cannabis sativa, along with their endogenous counterparts and synthetic derivatives, have elicited anti-cancer effects in many different in vitro and in vivo models of cancer. While the various cannabinoids have been examined in a variety of cancer models, recent studies have focused on the role of cannabinoid receptor agonists (both CB1 and CB2) in the treatment of estrogen receptor-negative breast cancer. This review will summarize the anti-cancer properties of the cannabinoids, discuss their potential mechanisms of action, as well as explore controversies surrounding the results. (C) 2009 Elsevier Ireland Ltd. All rights reserved.

引用

页码：6 / 12

页数：7

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