Adult Living Liver Donors have Excellent Long-Term Medical Outcomes: The University of Toronto Liver Transplant Experience

被引：86

作者：

Adcock, L. ^{[1
]}

Macleod, C. ^{[1
]}

Dubay, D. ^{[1
]}

Greig, P. D. ^{[1
]}

Cattral, M. S. ^{[1
]}

McGilvray, I. ^{[1
]}

Lilly, L. ^{[1
]}

Girgrah, N. ^{[1
]}

Renner, E. L. ^{[1
]}

Selzner, M. ^{[1
]}

Selzner, N. ^{[1
]}

Kashfi, A. ^{[1
]}

Smith, R. ^{[1
]}

Holtzman, S. ^{[1
]}

Abbey, S. ^{[1
]}

Grant, D. R. ^{[1
]}

Levy, G. A. ^{[1
]}

Therapondos, G. ^{[1
]}

机构：

[1] Univ Toronto, Toronto Gen Hosp, Univ Hlth Network,Multiorgan Transplant Program, Liver Transplant Program, Toronto, ON M5G 1L7, Canada

来源：

AMERICAN JOURNAL OF TRANSPLANTATION | 2010年 / 10卷 / 02期

关键词：

Donor hepatectomy; right lobe living donor liver transplantation; SINGLE-CENTER ANALYSIS; MIDDLE HEPATIC VEIN; RIGHT-LOBE; RIGHT HEPATECTOMY; PULMONARY-EMBOLISM; VANCOUVER FORUM; COMPLICATIONS; MORBIDITY; DONATION; LIFE;

D O I：

10.1111/j.1600-6143.2009.02950.x

中图分类号：

R61 [外科手术学];

学科分类号：

摘要：

Right lobe living donor liver transplantation is an effective treatment for selected individuals with end-stage liver disease. Although 1 year donor morbidity and mortality have been reported, little is known about outcomes beyond 1 year. Our objective was to analyze the outcomes of the first 202 consecutive donors performed at our center with a minimum follow-up of 12 months (range 12-96 months). All physical complications were prospectively recorded and categorized according to the modified Clavien classification system. Donors were seen by a dedicated family physician at 2 weeks, 1, 3 and 12 months postoperatively and yearly thereafter. The cohort included 108 males and 94 females (mean age 37.3 +/- 11.5 years). Donor survival was 100%. A total of 39.6% of donors experienced a medical complication during the first year after surgery (21 Grade 1, 27 Grade 2, 32 Grade 3). After 1 year, three donors experienced a medical complication (1 Grade 1, 1 Grade 2, 1 Grade 3). All donors returned to predonation employment or studies although four donors (2%) experienced a psychiatric complication. This prospective study suggests that living liver donation can be performed safely without any serious late medical complications and suggests that long-term follow-up may contribute to favorable donor outcomes.

引用

页码：364 / 371

页数：8

共 39 条

[1] Adult-to-adult living donor liver transplantation using right-lobe grafts: Results and lessons learned from a single-center experience [J].