State-dependent mechanisms of LTP expression revealed by optical quantal analysis

被引：45

作者：

Ward, Bonnie

McGuinness, Lindsay

Akerman, Colin J.

Fine, Alan

Bliss, Tim V. P.

Emptage, Nigel J.

机构：

[1] Univ Oxford, Dept Pharmacol, Oxford OX1 3QT, England

[2] Natl Inst Med Res, MRC, Div Neurophysiol, London NW7 1AA, England

[3] Dalhousie Univ, Fac Med, Dept Physiol & Biophys, Halifax, NS B3H 4H7, Canada

来源：

NEURON | 2006年 / 52卷 / 04期

基金：

英国医学研究理事会; 英国惠康基金;

关键词：

D O I：

10.1016/j.neuron.2006.10.007

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The expression mechanism of long-term potentiation (LTP) remains controversial. Here we combine electrophysiology and Ca2+ imaging to examine the role of silent synapses in LTP expression. Induction of LTP fails to change p(r) at these synapses but instead mediates an unmasking process that is sensitive to the inhibition of postsynaptic membrane fusion. Once unmasked, however, further potentiation of formerly silent synapses leads to an increase in p(r). The state of the synapse thus determines how LTP is expressed.

引用

收藏

页码：649 / 661

页数：13

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