Urinary excretion of deprenyl metabolites

被引：39

作者：

Lengyel, J

Magyar, K

Hollosi, I

Bartok, T

Bathori, M

Kalasz, H

Furst, S

机构：

[1] ALBERT SZENT GYORGYI MED UNIV, DEPT PHARMACOGNOSY, H-6701 SZEGED, HUNGARY

[2] SEMMELWEIS UNIV MED, CENT ISOTOPE LAB, H-1085 BUDAPEST, HUNGARY

[3] NATL INST PHYS EDUC & SPORTS, ANTIDOPING LAB, BUDAPEST, HUNGARY

[4] CEREAL RES INST, H-6701 SZEGED, HUNGARY

[5] SEMMELWEIS UNIV MED, DEPT PHARMACOL, H-1089 BUDAPEST, HUNGARY

来源：

JOURNAL OF CHROMATOGRAPHY A | 1997年 / 762卷 / 1-2期

关键词：

deprenyl metabolites; amphetamines; enzyme inhibitors;

D O I：

10.1016/S0021-9673(97)00009-5

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

(-)-Deprenyl metabolites in rat's urine, such as nordeprenyl, methamphetamine, amphetamine and p-hydroxy methamphetamine were identified by HPLC-MS. After oral administration of 10 mg of pure (-)- and (-)-deprenyl to human volunteers, their urine was analyzed by gas chromatography. The concentration of methamphetamine was found to be overwhelming in the case of the (-)-isomer, while amphetamine and methamphetamine were excreted in equal amounts when (+)-deprenyl was administered. The metabolic processes of deprenyl resulted in metabolites possessing different lipophilicity, as it has been shown by planar displacement chromatography.

引用

页码：321 / 326

页数：6

共 27 条

[1] DETERMINATION OF LIPOPHILICITY BY MEANS OF REVERSED-PHASE THIN-LAYER CHROMATOGRAPHY .1. BASIC ASPECTS AND RELATIONSHIP BETWEEN SLOPE AND INTERCEPT OF TLC EQUATIONS [J].