Liposomes and nanoparticles: nanosized vehicles for drug delivery in cancer

被引：954

作者：

Malam, Yogeshkumar ^{[1
,2
]}

Loizidou, Marilena ^{[2
]}

Seifalian, Alexander M. ^{[1
,2
,3
]}

机构：

[1] UCL, Ctr Nanotechnol Biomat & Tissue Engn, London, England

[2] UCL, UCL Div Surg & Intervent Sci, London, England

[3] Royal Free Hampstead NHS Trust Hosp, London, England

来源：

TRENDS IN PHARMACOLOGICAL SCIENCES | 2009年 / 30卷 / 11期

基金：

英国工程与自然科学研究理事会;

关键词：

SOLID LIPID NANOPARTICLES; FUNCTIONALIZED GOLD NANOPARTICLES; IN-VIVO; ANTICANCER ACTIVITY; QUANTUM DOTS; CARRIERS; CELLS; VITRO; DOXORUBICIN; ALBUMIN;

D O I：

10.1016/j.tips.2009.08.004

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Nanoscale drug delivery systems using liposomes and nanoparticles are emerging technologies for the rational delivery of chemotherapeutic drugs in the treatment of cancer. Their use offers improved pharmacokinetic properties, controlled and sustained release of drugs and, more importantly, lower systemic toxicity. The commercial availability of liposomal Doxil and albumin-nanoparticle-based Abraxane (R) has focused attention on this innovative and exciting field. Recent advances in liposome technology offer better treatment of multidrug-resistant cancers and lower cardiotoxicity. Nanoparticles offer increased precision in chemotherapeutic targeting of prostate cancer and new avenues for the treatment of breast cancer. Here we review current knowledge on the two technologies and their potential applications to cancer treatment.

引用

页码：592 / 599

页数：8

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