Evaluation of a neonatal rat model for prediction of mumps virus neurovirulence in humans

被引：52

作者：

Rubin, SA

Pletnikov, M

Taffs, R

Snoy, PJ

Kobasa, D

Brown, EG

Wright, KE

Carbone, KM

机构：

[1] US FDA, Ctr Biol Evaluat & Res, Bethesda, MD 20892 USA

[2] Johns Hopkins Univ, Dept Psychiat, Baltimore, MD 21218 USA

[3] Johns Hopkins Univ, Dept Med, Baltimore, MD 21218 USA

[4] Univ Ottawa, Dept Biochem Microbiol & Immunol, Ottawa, ON K1H 8M5, Canada

来源：

JOURNAL OF VIROLOGY | 2000年 / 74卷 / 11期

关键词：

D O I：

10.1128/JVI.74.11.5382-5384.2000

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Neurovirulence of several mumps virus strains was assessed in a prototype rat neurovirulence test and compared to results obtained in the monkey neurovirulence test. The relative human neurovirulence of these strains was proportional to the severity of hydrocephalus in rats but not to lesion scores in the monkeys.

引用

页码：5382 / 5384

页数：3

共 34 条

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DELCERRO M, 1975, LAB INVEST, V33, P608

[12] HYDROCEPHALUS IN HAMSTERS - INDUCTION BY NATURAL AND ATTENUATED MUMPS VIRUSES [J].