The correlation between levels of IL-7Rα expression and responsiveness to IL-7 is lost in CD4 lymphocytes from HIV-infected patients

被引：37

作者：

Colle, Jean-Herve ^{[1
]}

Moreau, Jean-Louis

Fontanet, Arnaud

Lambotte, Olivier

Delfraissy, Jean-Francois

Theze, Jacques

机构：

[1] Inst Pasteur, Unite Immunogenet Cellulaire, Dept Infect & Epidemiol, Paris, France

[2] Inst Pasteur, Unite Rech & Expertise Epidemiol Malad Emergentes, Paris, France

[3] Hop Bicetre, Serv Med Interne, Le Kremlin Bicetre, France

来源：

AIDS | 2007年 / 21卷 / 01期

关键词：

D O I：

10.1097/QAD.0b013e3280115b6a

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Measurements of Bcl-2 and CD25 expression suggested that IL-7R function is modified in CD4 lymphocytes of untreated viraemic patients. The extent of IL-7R function restoration post-HAART was analysed. A positive linear relationship was demonstrated between IL-7R alpha expression and the magnitude of IL-7-induced responses in healthy individuals, whereas this relationship is lost in HIV-infected patients, suggesting that viraemic patients suffer a receptor signaling transduction defect in IL-7R function. IL-7 responsiveness is only partly restored by HAART.

引用

页码：101 / 103

页数：3

共 10 条

[1] HIV infection:: pre-highly active antiretroviral therapy IL-7 plasma levels correlate with long-term CD4 cell count increase after treatment [J].

Beq, S ;

Rannou, MT ;

Fontanet, A ;

Delfraissy, JF ;

Thèze, J ;

Colle, JH .

AIDS, 2004, 18 (03) :563-565

[2] Regulatory dysfunction of the interleukin-7 receptor in CD4 and CD8 lymphocytes from HIV-infected patients -: Effects of antiretroviral therapy [J].

Colle, Jean-Herve ;

Moreau, Jean-Louis ;

Fontanet, Arnaud ;

Lambotte, Olivier ;

Joussemet, Marcel ;

Jacod, Sylvie ;

Delfraissy, Jean-Francois ;

Theze, Jacques .

JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES, 2006, 42 (03) :277-285

[3] Regulatory dysfunction of the interleukin-2 receptor during HIV infection and the impact of triple combination therapy [J].

David, D ;

Bani, L ;

Moreau, JL ;

Treilhou, MP ;

Nakarai, T ;

Joussemet, M ;

Ritz, J ;

Dupont, B ;

Pialoux, G ;

Thèze, J .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (19) :11348-11353

[4] The many faces of IL-7: From lymphopoiesis to peripheral T cell maintenance [J].

Fry, TJ ;

Mackall, CL .

JOURNAL OF IMMUNOLOGY, 2005, 174 (11) :6571-6576

[5] Cell biology of IL-7, a key lymphotrophin [J].

Jiang, Q ;

Li, WQ ;

Aiello, FB ;

Mazzucchelli, R ;

Asefa, B ;

Khaled, AR ;

Durum, SK .

CYTOKINE & GROWTH FACTOR REVIEWS, 2005, 16 (4-5) :513-533

[6] Defective interleukin-2-dependent STAT5 signalling in CD8 T lymphocytes from HIV-positive patients:: restoration by antiretroviral therapy [J].

Kryworuchko, M ;

Pasquier, V ;

Keller, H ;

David, D ;

Goujard, C ;

Gilquin, J ;

Viard, JP ;

Joussemet, M ;

Delfraissy, JF ;

Thèze, J .

AIDS, 2004, 18 (03) :421-426

[7]

MacPherson PA, 2001, J ACQ IMMUN DEF SYND, V28, P454, DOI 10.1097/00042560-200112150-00008

[8] Increased production of IL-7 accompanies HIV-l-mediated T-cell depletion: implications for T-cell homeostasis [J].

Napolitano, LA ;

Grant, RM ;

Deeks, SG ;

Schmidt, D ;

De Rosa, SC ;

Herzenberg, LA ;

Herndier, BG ;

Andersson, J ;

McCune, JM .

NATURE MEDICINE, 2001, 7 (01) :73-79

[9] Loss of CD127 expression defines an expansion of effector CD8+ T cells in HIV-infected individuals [J].

Paiardini, M ;

Cervasi, B ;

Albrecht, H ;

Muthukumar, A ;

Dunham, R ;

Gordon, S ;

Radziewicz, H ;

Piedimonte, G ;

Magnani, M ;

Montroni, M ;

Kaech, SM ;

Weintrob, A ;

Altman, JD ;

Sodora, DL ;

Feinberg, MB ;

Silvestri, G .

JOURNAL OF IMMUNOLOGY, 2005, 174 (05) :2900-2909

[10] Suppression of IL7Rα transcription by IL-7 and other prosurvival cytokines:: A novel mechanism for maximizing IL-7-dependent T cell survival [J].

Park, JH ;

Yu, Q ;

Erman, B ;

Appelbaum, JS ;

Montoya-Durango, D ;

Grimes, JL ;

Singer, A .

IMMUNITY, 2004, 21 (02) :289-302

← 1 →