Streptococcus pneumoniae pilus subunits protect mice against lethal challenge

被引：119

作者：

Gianfaldoni, Claudia ^{[1
]}

Censini, Stefano ^{[1
]}

Hilleringmann, Markus ^{[1
]}

Moschioni, Monica ^{[1
]}

Facciotti, Claudia ^{[1
]}

Pansegrau, Werner ^{[1
]}

Masignani, Vega ^{[1
]}

Covacci, Antonello ^{[1
]}

Rappuoli, Rino ^{[1
]}

Barocchi, Michele Anne ^{[1
]}

Ruggiero, Paolo ^{[1
]}

机构：

[1] Novartis Vaccines & Diagnost Srl, Res Ctr, I-53100 Siena, Italy

来源：

INFECTION AND IMMUNITY | 2007年 / 75卷 / 02期

关键词：

D O I：

10.1128/IAI.01400-06

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Streptococcus pneumoniae is a major public health threat worldwide. The recent discovery that this pathogen possesses pili led us to investigate their protective abilities in a mouse model of intraperitoneal infection. Both active and passive immunization with recombinant pilus subunits afforded protection against lethal challenge with the S. pneumoniae serotype 4 strain TIGR4.

引用

页码：1059 / 1062

页数：4

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