Altered Th1/Th2 balance associated with nonmajor histocompatibility complex genes in collagen-induced arthritis in resistant and nonresistant rat strains

被引：31

作者：

Mussener, A ^{[1
]}

Lorentzen, JC ^{[1
]}

Kleinau, S ^{[1
]}

Klareskog, L ^{[1
]}

机构：

[1] UNIV HOSP, DEPT PATHOL, UPPSALA, SWEDEN

来源：

EUROPEAN JOURNAL OF IMMUNOLOGY | 1997年 / 27卷 / 03期

关键词：

arthritis; collagen-induced arthritis; cytokine regulation; genetics;

D O I：

10.1002/eji.1830270318

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Collagen-induced arthritis (CIA) is a T cell-dependent disease in which susceptibility is controlled by genes both within and outside the major histocompatibility complex (MHC). In the present study, we compared the humoral responses and kinetics of cytokine secretion patterns in the draining lymph nodes of arthritis-susceptible DA rats and arthritis-resistant F344 and DA MHC congenic PVG.1AV1 rats immunized with rat type II collagen (RCII) in incomplete Freund's adjuvant. The results demonstrate a marked humoral RCII response and a Th1 cytokine profile, with expression of interferon-gamma and interleukin (IL)-2 mRNA in DA rats; a limited humoral RCII response and a Th2 cytokine profile, with expression of IL-4 mRNA in arthritis-resistant F344 rats; and a marked humoral RCII response in arthritis-resistant PVG.1AV1 rats. However, in contrast to DA rats, PVG.1AV1 rats produce IgG1 autoantibodies which, together with strong expression of IL-4 mRNA, indicates the involvement of Th2 subsets. From these data, we conclude that non-MHC gene(s) determines the direction of the anti-RCII response towards a Th1 disease-promoting, or a Th2 disease-limiting response.

引用

页码：695 / 699

页数：5

共 25 条

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