Inflammasome-Associated Nucleotide-Binding Domain, Leucine-Rich Repeat Proteins and Inflammatory Diseases

被引：70

作者：

Jha, Sushmita ^{[2
]}

Ting, Jenny P-Y ^{[1
,3
]}

机构：

[1] Univ N Carolina, Sch Med, Lineberger Comprehens Canc Ctr, Chapel Hill, NC 27599 USA

[2] Univ N Carolina, Dept Cell & Mol Physiol, Chapel Hill, NC 27599 USA

[3] Univ N Carolina, Dept Microbiol & Immunol, Chapel Hill, NC 27599 USA

来源：

JOURNAL OF IMMUNOLOGY | 2009年 / 183卷 / 12期

基金：

美国国家卫生研究院;

关键词：

NF-KAPPA-B; INNATE IMMUNE-RESPONSE; MUCKLE-WELLS-SYNDROME; NALP3; INFLAMMASOME; IRAK-4; INHIBITORS; CIAS1; MUTATIONS; DANGER SIGNAL; CASPASE-1; ACTIVATION; MURAMYL DIPEPTIDE; CUTTING EDGE;

D O I：

10.4049/jimmunol.0902425

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The nucleotide-binding domain, leucine-rich repeat (NLR) proteins a-re a recently discovered family of intracellular pathogen and danger signal sensors. NLRs have emerged as important contributors to innate immunity in animals. The physiological impact of these genes is increasingly evident, underscored by the genetic association of variant family members with an array of inflammatory diseases. The association of mutations in NLR genes with autoinflammatory diseases indicates an important function of these genes in inflammation in vivo, This review summarizes the role of the inflammasome NLR proteins in innate immunity and inflammatory diseases and explores the possible utility of some of these NLRs as pharmacological targets. The Journal of Immunology, 2009, 183: 7623-7629.

引用

页码：7623 / 7629

页数：7

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