Targeting IL-1 in inflammatory disease: New opportunities for therapeutic intervention

被引：199

作者：

Braddock, M

Quinn, A

机构：

[1] AstraZeneca R&D Charnwood, Dis Sci Sect, Discovery Biosci Dept, Loughborough LE11 5RH, Leics, England

[2] AstraZeneca R&D Charnwood, Dept Expt Med, Loughborough LE11 5RH, Leics, England

来源：

NATURE REVIEWS DRUG DISCOVERY | 2004年 / 3卷 / 04期

关键词：

D O I：

10.1038/nrd1342

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The cytokine interleukin-1 (IL-1) is important in many human diseases, and drives a wide range of inflammatory responses in a number of cell types. Biological agents that target IL-1 neutralization have shown efficacy in patients with rheumatoid arthritis. Recently, new classes of compounds that target IL-1 production or processing, or regulatory steps on the IL-1 pathway, are being investigated as new drugs for the management of inflammatory disease. Such compounds will have wide utility in numerous inflammatory conditions.

引用

页码：1 / 10

页数：10

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