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Targeting IL-1 in inflammatory disease: New opportunities for therapeutic intervention

被引：199
作者：
Braddock, M
Quinn, A
机构：
[1] AstraZeneca R&D Charnwood, Dis Sci Sect, Discovery Biosci Dept, Loughborough LE11 5RH, Leics, England
[2] AstraZeneca R&D Charnwood, Dept Expt Med, Loughborough LE11 5RH, Leics, England
来源：
NATURE REVIEWS DRUG DISCOVERY | 2004年 / 3卷 / 04期
关键词：
D O I：
10.1038/nrd1342
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
The cytokine interleukin-1 (IL-1) is important in many human diseases, and drives a wide range of inflammatory responses in a number of cell types. Biological agents that target IL-1 neutralization have shown efficacy in patients with rheumatoid arthritis. Recently, new classes of compounds that target IL-1 production or processing, or regulatory steps on the IL-1 pathway, are being investigated as new drugs for the management of inflammatory disease. Such compounds will have wide utility in numerous inflammatory conditions.
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页码：1 / 10
页数：10
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