学术探索
学术期刊
文章热点
数据分析
智能智评

Targeting IL-1 in inflammatory disease: New opportunities for therapeutic intervention

被引：199
作者：
Braddock, M
Quinn, A
机构：
[1] AstraZeneca R&D Charnwood, Dis Sci Sect, Discovery Biosci Dept, Loughborough LE11 5RH, Leics, England
[2] AstraZeneca R&D Charnwood, Dept Expt Med, Loughborough LE11 5RH, Leics, England
来源：
NATURE REVIEWS DRUG DISCOVERY | 2004年 / 3卷 / 04期
关键词：
D O I：
10.1038/nrd1342
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
The cytokine interleukin-1 (IL-1) is important in many human diseases, and drives a wide range of inflammatory responses in a number of cell types. Biological agents that target IL-1 neutralization have shown efficacy in patients with rheumatoid arthritis. Recently, new classes of compounds that target IL-1 production or processing, or regulatory steps on the IL-1 pathway, are being investigated as new drugs for the management of inflammatory disease. Such compounds will have wide utility in numerous inflammatory conditions.
引用
收藏
页码：1 / 10
页数：10
相关论文
共 106 条
  • [51] Guler HP, 2001, ARTHRITIS RHEUM, V44, pS370
  • [52] Potential therapeutic uses of interleukin 1 receptor antagonists in human diseases
    Hallegua, DS
    Weisman, MH
    [J]. ANNALS OF THE RHEUMATIC DISEASES, 2002, 61 (11) : 960 - 967
  • [53] INHIBITION OF INTERLEUKIN-1-INDUCED SYNOVITIS AND ARTICULAR-CARTILAGE PROTEOGLYCAN LOSS IN THE RABBIT KNEE BY RECOMBINANT HUMAN INTERLEUKIN-1 RECEPTOR ANTAGONIST
    HENDERSON, B
    THOMPSON, RC
    HARDINGHAM, T
    LEWTHWAITE, J
    [J]. CYTOKINE, 1991, 3 (03) : 246 - 249
  • [54] Functions of interleukin 1 receptor antagonist in gene knockout and overproducing mice
    Hirsch, E
    Irikura, VM
    Paul, SM
    Hirsh, D
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1996, 93 (20) : 11008 - 11013
  • [55] LL-Z1271α:: An interleukin-1β production inhibitor
    Ichikawa, K
    Inagaki, T
    Kachi-Tonai, H
    Kojima, Y
    Nakamura, T
    Nishida, H
    Ueno, Y
    Binding, P
    Gabel, CA
    Lucas, V
    McNiff, PA
    Kojima, N
    [J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2001, 286 (04) : 697 - 700
  • [56] Novel cytokine production inhibitors produced by a basidiomycete, Marasmiellus sp.
    Ichikawa, K
    Hirai, H
    Ishiguro, M
    Kambara, T
    Kato, Y
    Kim, YJ
    Kojima, Y
    Matsunaga, Y
    Nishida, H
    Shiomi, Y
    Yoshikawa, N
    Kojima, N
    [J]. JOURNAL OF ANTIBIOTICS, 2001, 54 (09) : 703 - 709
  • [57] CYTOKINE MESSENGER-RNA PROFILES IN INFLAMMATORY BOWEL-DISEASE MUCOSA DETECTED BY POLYMERASE CHAIN-REACTION AMPLIFICATION
    ISAACS, KL
    SARTOR, RB
    HASKILL, S
    [J]. GASTROENTEROLOGY, 1992, 103 (05) : 1587 - 1595
  • [58] Functional diversity and regulation of different interleukin-1 receptor-associated kinase (IRAK) family members
    Janssens, S
    Beyaert, R
    [J]. MOLECULAR CELL, 2003, 11 (02) : 293 - 302
  • [59] Jiang YB, 2000, ARTHRITIS RHEUM, V43, P1001, DOI 10.1002/1529-0131(200005)43:5<1001::AID-ANR7>3.0.CO
  • [60] 2-P
12345678910