Animal models of portal hypertension

被引：93

作者：

Abraldes, Juan G. ^{[1
]}

Pasarin, Marcos ^{[1
]}

Garcia-Pagan, Juan Carlos ^{[1
]}

机构：

[1] Univ Barcelona, IDIBAPS, Hosp Clin, ICMDiM,Hepat Hemodynam Lab,Liver Unit, E-08036 Barcelona, Spain

来源：

WORLD JOURNAL OF GASTROENTEROLOGY | 2006年 / 12卷 / 41期

关键词：

cirrhosis; nitric oxide; portal vein;

D O I：

10.3748/wjg.v12.i41.6577

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Animal models have allowed detailed study of hemodynamic alterations typical of portal hypertension and the molecular mechanisms involved in abnormalities in splanchnic and systemic circulation associated with this syndrome. Models of prehepatic portal hypertension can be used to study alterations in the splanchnic circulation and the pathophysiology of the hyperdynamic circulation. Models of cirrhosis allow study of the alterations in intrahepatic microcirculation that lead to increased resistance to portal flow. This review summarizes the currently available literature on animal models of portal hypertension and analyzes their relative utility. The criteria for choosing a particular model, depending on the specific objectives of the study, are also discussed. (C) 2006 The WJG Press. All rights reserved.

引用

页码：6577 / 6584

页数：8

共 82 条

[1] Mild increases in portal pressure upregulate vascular endothelial growth factor and endothelial nitric oxide synthase in the intestinal microcirculatory bed, leading to a hyperdynamic state [J].