Animal models of portal hypertension

被引：93

作者：

Abraldes, Juan G. ^{[1
]}

Pasarin, Marcos ^{[1
]}

Garcia-Pagan, Juan Carlos ^{[1
]}

机构：

[1] Univ Barcelona, IDIBAPS, Hosp Clin, ICMDiM,Hepat Hemodynam Lab,Liver Unit, E-08036 Barcelona, Spain

来源：

WORLD JOURNAL OF GASTROENTEROLOGY | 2006年 / 12卷 / 41期

关键词：

cirrhosis; nitric oxide; portal vein;

D O I：

10.3748/wjg.v12.i41.6577

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Animal models have allowed detailed study of hemodynamic alterations typical of portal hypertension and the molecular mechanisms involved in abnormalities in splanchnic and systemic circulation associated with this syndrome. Models of prehepatic portal hypertension can be used to study alterations in the splanchnic circulation and the pathophysiology of the hyperdynamic circulation. Models of cirrhosis allow study of the alterations in intrahepatic microcirculation that lead to increased resistance to portal flow. This review summarizes the currently available literature on animal models of portal hypertension and analyzes their relative utility. The criteria for choosing a particular model, depending on the specific objectives of the study, are also discussed. (C) 2006 The WJG Press. All rights reserved.

引用

收藏

页码：6577 / 6584

页数：8

相关论文

共 82 条

[31] HEMODYNAMIC CHARACTERIZATION IN EXPERIMENTAL LIVER-CIRRHOSIS INDUCED BY THIOACETAMIDE ADMINISTRATION [J].

HORI, N ;

OKANOUE, T ;

SAWA, Y ;

MORI, T ;

KASHIMA, K .

DIGESTIVE DISEASES AND SCIENCES, 1993, 38 (12) :2195-2202

[32] Mice with targeted deletion of eNOS develop hyperdynamic circulation associated with portal hypertension [J].

Iwakiri, Y ;

Cadelina, G ;

Sessa, WC ;

Groszmann, RJ .

AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY, 2002, 283 (05) :G1074-G1081

[33] A DIMETHYLNITROSAMINE-INDUCED MODEL OF CIRRHOSIS AND PORTAL-HYPERTENSION IN THE RAT [J].

JENKINS, SA ;

GRANDISON, A ;

BAXTER, JN ;

DAY, DW ;

TAYLOR, I ;

SHIELDS, R .

JOURNAL OF HEPATOLOGY, 1985, 1 (05) :489-499

[34] TEMPORAL RELATIONSHIP BETWEEN HYPER-ALDOSTERONISM, SODIUM RETENTION AND ASCITES FORMATION IN RATS WITH EXPERIMENTAL CIRRHOSIS [J].

JIMENEZ, W ;

MARTINEZPARDO, A ;

ARROYO, V ;

BRUIX, J ;

RIMOLA, A ;

GAYA, J ;

RIVERA, F ;

RODES, J .

HEPATOLOGY, 1985, 5 (02) :245-250

[35]

JIMENEZ W, 1992, J GASTROEN HEPATOL, V7, P9097

[36] INTESTINAL MICROVASCULAR RESPONSIVENESS TO NOREPINEPHRINE IN CHRONIC PORTAL-HYPERTENSION [J].

JOH, T ;

GRANGER, DN ;

BENOIT, JN .

AMERICAN JOURNAL OF PHYSIOLOGY, 1991, 260 (04) :H1135-H1143

[37] Enhanced carbon tetrachloride-induced liver fibrosis in mice lacking adiponectin [J].

Kamada, Y ;

Tamura, S ;

Kiso, S ;

Matsumoto, H ;

Saji, Y ;

Yoshida, Y ;

Fukui, K ;

Maeda, N ;

Nishizawa, H ;

Nagaretani, H ;

Okamoto, Y ;

Kihara, S ;

Miyagawa, J ;

Shinomura, Y ;

Funahashi, T ;

Matsuzawa, Y .

GASTROENTEROLOGY, 2003, 125 (06) :1796-1807

[38] Endothelin-1 modulates intrahepatic resistance in a rat model of noncirrhotic portal hypertension [J].

Kamath, PS ;

Tyce, GM ;

Miller, VM ;

Edwards, BS ;

Rorie, DK .

HEPATOLOGY, 1999, 30 (02) :401-407

[39] Hepatocyte transplantation in rats with decompensated cirrhosis [J].

Kobayashi, N ;

Ito, M ;

Nakamura, J ;

Cai, J ;

Gao, C ;

Hammel, JM ;

Fox, IJ .

HEPATOLOGY, 2000, 31 (04) :851-857

[40]

KOUNTOURAS J, 1984, BRIT J EXP PATHOL, V65, P305

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