Synthesis and structure-activity relationships of novel THF 1 beta-methylcarbapenems

被引：15

作者：

Lin, YI

Bitha, P

Sakya, SM

Strohmeyer, TW

Li, Z

Lee, VJ

Lang, SA

Yang, YJ

Bhachech, N

Weiss, WJ

Petersen, PJ

Jacobus, NV

Bush, K

Testa, RT

Tally, FP

机构：

[1] Wyeth-Ayerst Research, Div. of Amer. Home Prod. Corporation, Infectious Diseases Research Section, Pearl River

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1997年 / 7卷 / 13期

关键词：

D O I：

10.1016/S0960-894X(97)00282-5

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A series of twelve highly active aminomethyl-THF 1 beta-methylcarbapenems 3a-1 were synthesized. Of these, carbapenems 3a-f demonstrated a spectrum of antimicrobial activity comparable to those of imipenem and meropenem with the exception of only moderate anti-pseudomonal activity. Most importantly, they demonstrated moderate intrinsic oral activity against an E. coli infection in mice. (C) 1997 Elsevier Science Ltd.

引用

页码：1671 / 1676

页数：6

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