Peptidic prodrugs of novel aminomethyl-THF 1 beta-methylcarbapenems

被引：12

作者：

Lin, YI

Bitha, P

Sakya, SM

Li, Z

Lang, SA

Yang, YJ

Bhachech, N

Weiss, WJ

Petersen, PJ

Jacobus, NV

Bush, K

Testa, RT

机构：

[1] Wyeth-Ayerst Research, Div. of Amer. Home Prod. Corporation, Infectious Diseases Research Section, Pearl River

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1997年 / 7卷 / 13期

关键词：

D O I：

10.1016/S0960-894X(97)00281-3

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Peptidic prodrugs of the five most active aminomethyl-THF 1 beta-methylcarbapenems were synthesized. Of these, only L-amino acid derivatives from la demonstrated an improved oral activity. These results indicate that the L-amino acid derivatives from la are orally absorbed most likely through the dipeptide and tripeptide transport mechanism. (C) 1997 Elsevier Science Ltd.

引用

页码：1665 / 1670

页数：6

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