Mechanisms linking obesity to insulin resistance and type 2 diabetes

被引：3761

作者：

Kahn, Steven E.

Hull, Rebecca L.

Utzschneider, Kristina M.

机构：

[1] VA Puget Sound Hlth Care Syst, Dept Med, Div Metab Endocrinol & Nutr, Seattle, WA 98108 USA

[2] Univ Washington, Seattle, WA 98108 USA

来源：

NATURE | 2006年 / 444卷 / 7121期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1038/nature05482

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Obesity is associated with an increased risk of developing insulin resistance and type 2 diabetes. In obese individuals, adipose tissue releases increased amounts of non-esterified fatty acids, glycerol, hormones, proinflammatory cytokines and other factors that are involved in the development of insulin resistance. When insulin resistance is accompanied by dysfunction of pancreatic islet beta-cells - the cells that release insulin failure to control blood glucose levels results. Abnormalities in beta-cell function are therefore critical in defining the risk and development of type 2 diabetes. This knowledge is fostering exploration of the molecular and genetic basis of the disease and new approaches to its treatment and prevention.

引用

页码：840 / 846

页数：7

共 83 条

[31] β-cell function is a major contributor to oral glucose tolerance in high-risk relatives of four ethnic groups in the US
Jensen, CC
Cnop, M
Hull, RL
Fujimoto, WY
Kahn, SE
[J]. DIABETES, 2002, 51 (07) : 2170 - 2178
[32] Adiponectin and adiponectin receptors in insulin resistance, diabetes, and the metabolic syndrome
Kadowaki, Takashi
Yamauchi, Toshimasa
Kubota, Naoto
Hara, Kazuo
Ueki, Kohjiro
Tobe, Kazuyuki
[J]. JOURNAL OF CLINICAL INVESTIGATION, 2006, 116 (07) : 1784 - 1792
[33] EXERCISE TRAINING DELINEATES THE IMPORTANCE OF B-CELL DYSFUNCTION TO THE GLUCOSE-INTOLERANCE OF HUMAN AGING
KAHN, SE
LARSON, VG
SCHWARTZ, RS
BEARD, JC
CAIN, KC
FELLINGHAM, GW
STRATTON, JR
CERQUEIRA, MD
ABRASS, IB
[J]. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1992, 74 (06) : 1336 - 1342
[34] The relative contributions of insulin resistance and beta-cell dysfunction to the pathophysiology of Type 2 diabetes
Kahn, SE
[J]. DIABETOLOGIA, 2003, 46 (01) : 3 - 19
[35] INCREASED BETA-CELL SECRETORY CAPACITY AS MECHANISM FOR ISLET ADAPTATION TO NICOTINIC-ACID INDUCED INSULIN RESISTANCE
KAHN, SE
BEARD, JC
SCHWARTZ, MW
WARD, WK
DING, HL
BERGMAN, RN
TABORSKY, GJ
PORTE, D
[J]. DIABETES, 1989, 38 (05) : 562 - 568
[36] Clinical review 135 -: The importance of β-cell failure in the development and progression of type 2 diabetes
Kahn, SE
[J]. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2001, 86 (09) : 4047 - 4058
[37] QUANTIFICATION OF THE RELATIONSHIP BETWEEN INSULIN SENSITIVITY AND BETA-CELL FUNCTION IN HUMAN-SUBJECTS - EVIDENCE FOR A HYPERBOLIC FUNCTION
KAHN, SE
PRIGEON, RL
MCCULLOCH, DK
BOYKO, EJ
BERGMAN, RN
SCHWARTZ, MW
NEIFING, JL
WARD, WK
BEARD, JC
PALMER, JP
PORTE, D
[J]. DIABETES, 1993, 42 (11) : 1663 - 1672
[38] EFFECT OF EXERCISE ON INSULIN ACTION, GLUCOSE-TOLERANCE, AND INSULIN-SECRETION IN AGING
KAHN, SE
LARSON, VG
BEARD, JC
CAIN, KC
FELLINGHAM, GW
SCHWARTZ, RS
VEITH, RC
STRATTON, JR
CERQUEIRA, MD
ABRASS, IB
[J]. AMERICAN JOURNAL OF PHYSIOLOGY, 1990, 258 (06): : E937 - E943
[39] SHORT-TERM HYPERGLYCEMIA AND HYPERINSULINEMIA IMPROVE INSULIN ACTION BUT DO NOT ALTER GLUCOSE ACTION IN NORMAL HUMANS
KAHN, SE
BERGMAN, RN
SCHWARTZ, MW
TABORSKY, GJ
PORTE, D
[J]. AMERICAN JOURNAL OF PHYSIOLOGY, 1992, 262 (04): : E518 - E523
[40] Reduced β-cell function contributes to impaired glucose tolerance in dogs made obese by high-fat feeding
Kaiyala, KJ
Prigeon, RL
Kahn, SE
Woods, SC
Porte, D
Schwartz, MW
[J]. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM, 1999, 277 (04): : E659 - E667

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