Dipeptides bearing nucleobases for the synthesis of novel peptide nucleic acids

被引:25
作者
Lowe, G
Vilaivan, T
机构
[1] Dyson Perrins Laboratory, Oxford University, Oxford OX1 3QY, South Parks Road
来源
JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1 | 1997年 / 04期
关键词
D O I
10.1039/a603699f
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
Three stereoisomers (cis-L, trans-D and cis-D) of N-Fmoc-glycyl-4-(thymin-1-yl)proline and their pentafluorophenyl esters have been prepared for use in the synthesis of novel peptide nucleic acids. In addition, N-Fmoc-glycyl-4(N-6-benzoyladenin-9-yl)proline, N-Fmoc-glycyl-4-(N-4-benzoylcytosin-1-yl)proline and N-Fmoc-glycyl-4-(N-2-isobutyrylguanin-9-yl)proline and their pentafluorophenyl esters of the cis-D series have been synthesized.
引用
收藏
页码:547 / 554
页数:8
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