Use of a single monoclonal antibody to determine the susceptibilities of herpes simplex virus type 1 and type 2 clinical isolates to acyclovir

被引：2

作者：

Chutkowski, C

Olson, B

McDonough, A

Mahoney, J

McSharry, JJ

机构：

[1] Albany Med Coll, Ctr Immunol & Microbial Dis, Albany Med Ctr, Albany, NY 12208 USA

[2] McMaster Univ, St Joseph Hosp, Reg Virol Lab, Hamilton, ON, Canada

来源：

CLINICAL AND DIAGNOSTIC LABORATORY IMMUNOLOGY | 2002年 / 9卷 / 06期

关键词：

D O I：

10.1128/CDLI.9.6.1379-1381.2002

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

This report describes a How cytometry drug susceptibility assay that uses a single fluorochrome-labeled monoclonal antibody to determine the acyclovir susceptibilities of herpes simplex virus (HSV) type 1 or type 2 clinical isolates. This assay yields 50% effective doses (drug concentrations that reduce the number of antigen-positive cells by 50%) for HSV clinical isolates that are equivalent to those obtained with the plaque reduction assay.

引用

页码：1379 / 1381

页数：3

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