Epoxy-functionalized large-pore SBA-15 and KIT-6 as affinity chromatography supports

被引：34

作者：

Calin, Nathalie ^{[1
]}

Galarneau, Anne ^{[1
]}

Cacciaguerra, Thomas ^{[1
]}

Denoyel, Renaud ^{[2
]}

Fajula, Francois ^{[1
]}

机构：

[1] ENSCM, CNRS, Inst Charles Gerhardt, UM2,Mat Avances Catalyse & Sante UM1 UMR 5253, F-34296 Montpellier 5, France

[2] Univ Aix Marseille 1, CNRS, UMR Madirel 6121, Ctr St Jerome, F-13397 Marseille 20, France

来源：

COMPTES RENDUS CHIMIE | 2010年 / 13卷 / 1-2期

关键词：

SBA-15; KIT-6; Affinity chromatography support; Mesoporous silica; MESOPOROUS SILICA; MESOSTRUCTURED SILICAS; LIQUID-CHROMATOGRAPHY; CYLINDRICAL PORES; ADSORPTION; COPOLYMER; TRIBLOCK; SPHERES; SIZE; IMMOBILIZATION;

D O I：

10.1016/j.crci.2009.04.001

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Mesoporous silica supports are proposed as an alternative to polymeric stationary phases for fast affinity chromatography due to their better mechanical strength compared to polymers Ideal supports should combine high surface area and large pore size to allow a high loading capacity of large molecules, such as proteins, and favor their accessibility Increasing the pore size of large-surface area micelle-templated silicas (SBA-15, KIT-6) has been achieved by swelling the micelles by the addition of organic molecules and increasing synthesis lime and temperature. The pore size of hexagonal silica mesostructured SBA-15 has been increased up to 35 nm These materials could find therefore application as affinity chromatography for immunoextraction To cite this article: N. Calin et al., C. R. Chimie 13 (2010). (C) 2009 Published by Elsevier Masson SAS on behalf of Academic des sciences

引用

页码：199 / 206

页数：8

共 36 条

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