Analysis of nitrofuran residues in animal feed using liquid chromatography and photodiode-array detection

被引：30

作者：

Vinas, P. ^{[1
]}

Campillo, N. ^{[1
]}

Carrasco, L. ^{[1
]}

Hernandez-Cordoba, M. ^{[1
]}

机构：

[1] Univ Murcia, Fac Chem, Dept Analyt Chem, E-30071 Murcia, Spain

来源：

CHROMATOGRAPHIA | 2007年 / 65卷 / 1-2期

关键词：

column liquid chromatography; nitrofuran in animal feed; nitrofurantoin; furazolidone; furaltadone; nitrofurazone;

D O I：

10.1365/s10337-006-0112-7

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

The analysis of four nitrofuran veterinary drugs, nitrofurantoin, furazolidone, furaltadone and nitrofurazone, was optimized using reversed-phase liquid chromatography with a monolithic column and photo-diode array detection. The antibiotics were extracted from animal feeds by heating with acetonitrile. The isocratic mobile phase consisted of a 8:92 (v/v) acetonitrile/ phosphate buffer (pH 4.5) at a flow-rate of 1 mL min(-1). Peaks were identified by the retention characteristics and UV spectra. Detection limits in the water samples ranged between 0.21 and 0.27 mu g L-1, and in the feed samples between 2.1 and 2.7 mu g kg(-1), depending on the nitrofuran, The procedure was applied to the control of nitrofuran residues in farm water for poultry and different animal feeds.

引用

页码：85 / 89

页数：5

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