Hormesis commonly observed in the assessment of aneuploidy in yeast

被引：25

作者：

Calabrese, Edward J. ^{[1
]}

机构：

[1] Univ Massachusetts, Dept Environm Hlth Sci, Morrill 1,N344, Amherst, MA 01003 USA

来源：

ENVIRONMENTAL POLLUTION | 2017年 / 225卷

关键词：

Hormesis; Biphasic dose response; Aneuploidy; Genotoxicity; Yeast; DIPLOID MEIOTIC PRODUCTS; HORMETIC DOSE RESPONSES; SACCHAROMYCES-CEREVISIAE; TOXICOLOGICAL LITERATURE; METHYL METHANESULFONATE; CHROMOSOME LOSS; NONDISJUNCTION; CYCLOPHOSPHAMIDE; SEGREGATION; INDUCTION;

D O I：

10.1016/j.envpol.2017.03.020

中图分类号：

X [环境科学、安全科学];

学科分类号：

083001 [环境科学];

摘要：

Extensive dose response studies have assessed the potential of toxic chemical agents to induce aneuploidy in the yeast model. An assessment of such findings revealed that hormetic-like biphasic dose responses were commonly observed. A preliminary estimate of the frequency of the hormetic responses using a priori entry and evaluative criteria was approximately 65-80%. (C) 2017 Published by Elsevier Ltd.

引用

页码：713 / 728

页数：16

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