Serum uric acid and cognitive function in community-dwelling older adults

被引：95

作者：

Schretlen, David J.

Inscore, Anjeli B.

Jinnah, H. A.

Rao, Vani

Gordon, Barry

Pearlson, Godfrey D.

机构：

[1] Johns Hopkins Univ, Sch Med, Dept Psychiat & Behav Sci, Baltimore, MD 21218 USA

[2] Johns Hopkins Univ, Sch Med, Dept Radiol & Radiol Sci, Baltimore, MD 21218 USA

[3] Johns Hopkins Univ, Sch Med, Dept Psychiat & Behav Sci, Baltimore, MD 21218 USA

[4] Johns Hopkins Univ, Sch Med, Dept Neurol, Baltimore, MD 21218 USA

[5] Hartford Hosp, Inst Living, Olin Neuropsychiat Res Ctr, Hartford, CT USA

[6] Yale Univ, Sch Med, Dept Psychiat, New Haven, CT 06520 USA

来源：

NEUROPSYCHOLOGY | 2007年 / 21卷 / 01期

关键词：

cognitive aging; biomarker; uric acid; cardiovascular disease; mild cognitive impairment;

D O I：

10.1037/0894-4105.21.1.136

中图分类号：

B849 [应用心理学];

学科分类号：

040203 ;

摘要：

Among possible markers of age-related cognitive decline, uric acid (UA) is controversial because it has antioxidant properties but is increased in diseases that often lead to cognitive impairment. In this study of 96 elderly adults, participants with mildly elevated (but normal) serum UA were 2.7 to 5.9 times more likely to score in the lowest quartile of the sample on measures of processing speed, verbal memory, and working memory. Even after controlling for age, sex, race, education, diabetes, hypertension, smoking, and alcohol abuse, the multivariate-adjusted odds of poor verbal memory and working memory remained significant (ps <.05). Despite its antioxidant properties, these findings suggest that even mild elevations of UA might increase the risk of cognitive decline among older adults.

引用

页码：136 / 140

页数：5

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