CTLA-4 upregulation during aging

被引：45

作者：

Leng, QB

Bentwich, Z

Borkow, G ^{[1
]}

机构：

[1] Hebrew Univ, Hadassah Med Sch, Kaplan Med Ctr, Ruth Ben Ari Inst Clin Immunol, IL-76100 Rehovot, Israel

[2] Hebrew Univ, Hadassah Med Sch, Kaplan Med Ctr, AIDS Ctr, IL-76100 Rehovot, Israel

来源：

MECHANISMS OF AGEING AND DEVELOPMENT | 2002年 / 123卷 / 10期

关键词：

CTLA-4; aging; anergy; immune activation; CD28;

D O I：

10.1016/S0047-6374(02)00077-5

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The immune system gradually becomes anergic with age. Here, we measured intracellular levels of cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4), a negative regulator of T-cells, in 53 healthy individuals aged 18-94. We found a highly significant correlation between age and percent of CTLA-4+CD4+cells (r = 0. 6, P < 0.001) and between age and mean fluorescence intensities of CTLA-4 (i.e. number of molecules, r = 0.61, P < 0.001). CTLA-4 levels were also correlated with immune activation, determined by levels of HLA-DR + CD3 + cells (r = 0.55, P < 0.001). We postulate that immune senescence associated with age is caused in part by chronic immune activation with related decrease in CD28 costimulatory molecules and increase in inhibitory CTLA-4 molecules. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：1419 / 1421

页数：3

共 18 条

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[2]

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