H-NMR assay of papaverine hydrochloride and formulations

被引：4

作者：

Aboutabl, EA

El-Azzouny, AA

Afifi, MS

机构：

[1] Cairo Univ, Fac Pharm, Dept Pharmacognosy, Cairo 11562, Egypt

[2] Natl Res Ctr, Dept Pharmaceut Sci, Cairo, Egypt

[3] Natl Res Ctr, Chem Nat & Microbial Prod Dept, Cairo, Egypt

来源：

PHYTOCHEMICAL ANALYSIS | 2002年 / 13卷 / 06期

关键词：

proton NMR; quantitative assay; papaverine hydrochloride; assay of tablets; assay of injections;

D O I：

10.1002/pca.657

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

A precise and specific H-1-NMR method has been developed for the assay of papaverine hydrochloride (1) as a bulk drug, as well as in tablet and injection dosage forms. The assay depends upon the integration of the 12 protons of the four methoxy groups of I relative to that of the three methyl protons of acetanilide (internal standard). In addition to the accurate quantitative determination of 1, the method provides a specific means of identifying I as well as detecting other alkaloids or impurities. Copyright (C) 2002 John Wiley Sons, Ltd.

引用

页码：301 / 304

页数：4