Rationalization and prediction of solution enantiomeric excess in ternary phase systems

被引：122

作者：

Klussmann, Martin ^{[1
]}

White, Andrew J. R. ^{[1
]}

Armstrong, Alan ^{[1
]}

Blackmond, Donna G. ^{[1
]}

机构：

[1] Univ London Imperial Coll Sci & Technol, Dept Chem, London SW7 2AZ, England

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2006年 / 45卷 / 47期

关键词：

amino acids; chirality; enantioselectivity; phase diagrams; solvent effects;

D O I：

10.1002/anie.200602520

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(Figure Presented) Solubility and enantiomeric excess: A general model based on simple solubility concepts rationalizes the value of the ee at the eutectic for a wide range of chiral substances including amino acids and common chiral ligands. A novel crystal structure in which one CHCl3 molecule is incorporated in a highly insoluble (α = 0.002) proline racemate explains the strong asymmetric amplification observed in the proline/CHCl 3 system. © 2006 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：7985 / 7989

页数：5

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