ESI mass spectrometry and X-ray diffraction studies of adducts between anticancer platinum drugs and hen egg white lysozyme

被引：137

作者：

Casini, Angela

Mastrobuoni, Guido

Temperini, Claudia

Gabbiani, Chiara

Francese, Simona

Moneti, Gloriano

Supuran, Claudiu T.

Scozzafava, Andrea

Messori, Luigi

机构：

[1] Univ Florence, Dept Chem, I-50019 Sesto Fiorentino, Italy

[2] Univ Florence, Mass Spectrometry Ctr, I-50019 Sesto Fiorentino, Italy

来源：

CHEMICAL COMMUNICATIONS | 2007年 / 02期

关键词：

D O I：

10.1039/b611122j

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The interactions of cisplatin and its analogues, transplatin, carboplatin and oxaliplatin, with hen egg white lysozyme were analysed through ESI mass spectrometry, and the resulting metallodrug-protein adducts identified; the X-ray crystal structure of the cisplatin lysozyme derivative, solved at 1.9 angstrom resolution, reveals selective platination of imidazole N epsilon of His15.

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页码：156 / 158

页数：3

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