Clinical aspects of nephropathia epidemica (Puumala virus infection) in Europe: A review

被引:76
作者
Settergren, B [1 ]
机构
[1] Karolinska Hosp, Dept Infect Dis, S-17176 Stockholm, Sweden
关键词
D O I
10.1080/003655400750045204
中图分类号
R51 [传染病];
学科分类号
100401 ;
摘要
Nephropathia epidemica (NE) is a prevalent zoonosis throughout Europe and is caused by the Puumala type of hantavirus, The incidence of NE varies in a cyclic fashion, with peaks occurring every 3rd to 4th year, coinciding with peaks in vole populations. The clinical course of NE is generally milder than haemorrhagic fever with renal syndrome caused by hantaviruses in other parts of the world, Typically, NE has a sudden onset with fever, headache, backpain and gastrointestinal symptoms. However, severe complications, e.g, gastrointestinal haemorrhage, occur and fatal cases have been reported. Renal involvement is prominent and manifests as initial oliguria and later as marked polyuria. Tests of renal function show pronounced glomerular and tubular involvement. Vaccine against Puumala virus infection as well as specific treatment for NE are still lacking.
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页码:125 / 132
页数:8
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