Friendly and dangerous signals: is the tissue in control?

被引:360
作者
Matzinger, Polly [1 ]
机构
[1] NIAID, Ghost Lab, Cellular & Mol Immunol Lab, NIH, Bethesda, MD 20892 USA
关键词
D O I
10.1038/ni0107-11
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
In their own defense, tissues send a panoply of signals that initiate immunity and guide the choice of effector class. T(H)1-T(H)2 and T-reg is far too simple a representation of the breathtaking variety of the resulting responses.
引用
收藏
页码:11 / 13
页数:3
相关论文
共 11 条
[1]   Autoreactivity by design: Innate B and T lymphocytes [J].
Bendelac, A ;
Bonneville, M ;
Kearney, JF .
NATURE REVIEWS IMMUNOLOGY, 2001, 1 (03) :177-186
[2]   Epithelial Cells and Their Neighbors. III. Interactions between intraepithelial lymphocytes and neighboring epithelial cells [J].
Havran, WL ;
Jameson, JM ;
Witherden, DA .
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY, 2005, 289 (04) :G627-G630
[3]   Intraepithelial lymphocytes: exploring the Third Way in immunology [J].
Hayday, A ;
Theodoridis, E ;
Ramsburg, E ;
Shires, J .
NATURE IMMUNOLOGY, 2001, 2 (11) :997-1003
[4]   THE IMMUNE-SYSTEM EVOLVED TO DISCRIMINATE INFECTIOUS NONSELF FROM NONINFECTIOUS SELF [J].
JANEWAY, CA .
IMMUNOLOGY TODAY, 1992, 13 (01) :11-16
[5]   Phenotype and function of intestinal dendritic cells [J].
Johansson, C ;
Kelsall, BL .
SEMINARS IN IMMUNOLOGY, 2005, 17 (04) :284-294
[6]  
MATZINGER P, 1994, ANNU REV IMMUNOL, V12, P991, DOI 10.1146/annurev.immunol.12.1.991
[7]   The danger model: A renewed sense of self [J].
Matzinger, P .
SCIENCE, 2002, 296 (5566) :301-305
[8]   Immunology of placentation in eutherian mammals [J].
Moffett, Ashley ;
Loke, Charlie .
NATURE REVIEWS IMMUNOLOGY, 2006, 6 (08) :584-594
[9]   Hydrophobicity: an ancient damage-associated molecular pattern that initiates innate immune responses [J].
Seong, SY ;
Matzinger, P .
NATURE REVIEWS IMMUNOLOGY, 2004, 4 (06) :469-478
[10]   RETRACTED: Induction of a homeostatic circuit in lung tissue by microbial compounds (Retracted Article. See vol 28, pg 724, 2008) [J].
Takabayshi, K ;
Corr, M ;
Hayashi, T ;
Redecke, V ;
Beck, L ;
Guiney, D ;
Sheppard, D ;
Raz, E .
IMMUNITY, 2006, 24 (04) :475-487