Chemoselective backbone cyclization of unprotected peptides

被引：90

作者：

Camarero, JA ^{[1
]}

Muir, TW ^{[1
]}

机构：

[1] ROCKEFELLER UNIV,LAB SYNTHET PROT CHEM,NEW YORK,NY 10021

来源：

CHEMICAL COMMUNICATIONS | 1997年 / 15期

关键词：

D O I：

10.1039/a702083j

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A fully unprotected 15 residue peptide containing an N-terminal Cys residue and a C-terminal thioester moiety is cleanly converted to the corresponding head-to-tail cyclic peptide in aqueous buffers at around neutral pH.

引用

页码：1369 / 1370

页数：2

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