Does dopamine dysfunction drive depression?

被引:65
作者
Malhi, G. S. [1 ]
Berk, M.
机构
[1] Univ Sydney, No Clin Sch, Acad Discipline Psychol Med, Sydney, NSW 2065, Australia
[2] Prince Wales Med Res Inst, Mayne Clin Imaging Ctr, Neurosci Res Grp, Sydney, NSW, Australia
[3] Black Dog Inst, Mood Disorders Unit, Sydney, NSW, Australia
[4] ORYGEN Res Ctr, Melbourne, Vic, Australia
[5] Univ Melbourne, Dept Clin & Biochem Sci, Barwon Hlth & Geelong Clin, Melbourne, Vic, Australia
关键词
melancholia; depression; dopamine; psychomotor; cognition; Parkinson's disease; review of the literature;
D O I
10.1111/j.1600-0447.2007.00969.x
中图分类号
R749 [精神病学];
学科分类号
100205 [精神病与精神卫生学];
摘要
Objective: To examine the evidence that dopamine (DA) dysfunction contributes to melancholic depression. Method: Database (EMBASE, PsychLit and MEDLINE) searches using relevant key words were conducted and citations were scrutinized. Results: In this paper, we assume that the definition of melancholia is contingent upon the presence of psychomotor disturbance (PMD). In melancholic depression PMD comprises both a cognitive and motor component and DA is found to be important in both. DA neurotransmission modulates cognition in particular in attention, adaptation and motivational processes and has a pivotal role in motor function. Conclusion: DA is a credible aetiological candidate for the PMD in melancholic depression. However, melancholia needs first to be characterized both clinically and in terms of its pathophysiology. In this regard, illnesses such as bipolar depression and Parkinson's disease warrant consideration as they provide suitable models of both the cognitive and motor aspects of PMD, and hold the necessary markers to better define melancholia.
引用
收藏
页码:116 / 124
页数:9
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