Trace measurement of phenothiazine drugs in tablets by micellar-enhanced fluorophotometric method

被引：12

作者：

Yang, Gong-Jun ^{[1
]}

Qu, Xi-Long ^{[1
]}

Shen, Ming ^{[1
]}

Qu, Qi-Shu ^{[1
]}

Wang, Chen-Ying ^{[1
]}

Zhu, Ai-Ping ^{[1
]}

Hu, Xiao-Ya ^{[1
]}

机构：

[1] Yangzhou Univ, Coll Chem & Chem Engn, Yangzhou 225002, Peoples R China

来源：

JOURNAL OF FLUORESCENCE | 2007年 / 17卷 / 02期

关键词：

phenothiazine drugs; micellar-enhanced fluorophotometric method; trace measurement;

D O I：

10.1007/s10895-007-0165-5

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

It was found that in buffer solution of pH 7.0, the addition of sodium dodecyl sulfate (SDS) to the solution of phenothiazine drugs, such as chlorpromazine, promethazine and trifluoperazine, showed a remarkable enhancement of their fluorescence intensity. A further study proved that the phenothiazine drugs can be determined by fluorophotometric method in micellar system. Under optimal conditions, there was a good linear relationship between fluorescence intensity and phenothiazine compounds concentration, and the detection limit of 3.0x10(-8) M chlorpromazine, 3.0x10(-8) M promethazine and 1.5x10(-8) M trifluoperazine (S/N=3) were also obtained. This method has been used to determine phenothiazine drugs in tablets with satisfactory results.

引用

页码：119 / 126

页数：8

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