Effect of isolation on pain threshold and on different effects of morphine

被引:26
作者
Coudereau, JP
Monier, C
Bourre, JM
Frances, H
机构
[1] INSERM U 26, Hôpital Fernand Widal, Paris
[2] INSERM U 26, Hôpital F. Widal, 75475 Paris Cédex 10
关键词
analgesia; dependence; mice; morphine; nociception; social isolation; tolerance;
D O I
10.1016/S0278-5846(97)00094-8
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
1. The effect of three periods of isolation (8, 15 and 30 days) were studied in mice on the pain treshold and the sensitivity to morphine. 2. The pain threshold was unchanged after 8 and 15 days of isolation but increased after 30 days of isolation. 3. The analgesic effect of morphine was unchanged after 8 and 15 days of isolation but increased after 30 days of isolation. 4. The tolerance to morphine analgesia was unchanged after 8 and 15 days of isolation but increased after 30 days of isolation (morphine-induced analgesia was reduced). 5. The physical dependence on morphine induced by precipitated withdrawal was unchanged after 8 and 15 days of isolation but decreased after 30 days of isolation. 6. It is suggested that isolation may modify the metabolism the metabolism/absorption of morphine in a different way according as the treatment is unique or chronic. (C) 1997 Elsevier Science Inc.
引用
收藏
页码:997 / 1018
页数:22
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