Emerging immune targets for the therapy of allergic asthma

被引:46
作者
Corry, DB [1 ]
机构
[1] Baylor Coll Med, Dept Med, Houston, TX 77030 USA
[2] Baylor Coll Med, Dept Immunol, Houston, TX 77030 USA
[3] Baylor Coll Med, Biol Inflammat Ctr, Houston, TX 77030 USA
关键词
D O I
10.1038/nrd702
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
Recent discoveries on the molecular and cellular basis of asthma have markedly altered our understanding of this common respiratory disorder. These insights have come during an unexplained period of rising disease incidence and severity and are now being applied to develop improved therapies. This review explores the latest advances in our understanding of the pathogenesis of allergic asthma, and provides insight into the expanding collaborations between research scientists, clinicians and the pharmaceutical industry in the race to control the asthma epidemic.
引用
收藏
页码:55 / 64
页数:10
相关论文
共 98 条
[1]   Functional diversity of helper T lymphocytes [J].
Abbas, AK ;
Murphy, KM ;
Sher, A .
NATURE, 1996, 383 (6603) :787-793
[2]  
Andrew DP, 1998, J IMMUNOL, V161, P5027
[3]   Heteromerization of the γc chain with the interleukin-9 receptor α subunit leads to STAT activation and prevention of apoptosis [J].
Bauer, JH ;
Liu, KD ;
You, Y ;
Lai, SY ;
Goldsmith, MA .
JOURNAL OF BIOLOGICAL CHEMISTRY, 1998, 273 (15) :9255-9260
[4]   Independent and epigenetic regulation of the interleukin-4 alleles in CD4+ T cells [J].
Bix, M ;
Locksley, RM .
SCIENCE, 1998, 281 (5381) :1352-1354
[5]   Genetic regulation of commitment to interleukin 4 production by a CD4+ T cell-intrinsic mechanism [J].
Bix, M ;
Wang, ZE ;
Thiel, B ;
Schork, NJ ;
Locksley, RM .
JOURNAL OF EXPERIMENTAL MEDICINE, 1998, 188 (12) :2289-2299
[6]  
Bliss J, 1996, J IMMUNOL, V156, P887
[7]   Impaired monocyte migration and reduced type 1 (Th1) cytokine responses in C-C chemokine receptor 2 knockout mice [J].
Boring, L ;
Gosling, J ;
Chensue, SW ;
Kunkel, SL ;
Farese, RV ;
Broxmeyer, HE ;
Charo, IF .
JOURNAL OF CLINICAL INVESTIGATION, 1997, 100 (10) :2552-2561
[8]   Efficacy of soluble IL-4 receptor for the treatment of adults with asthma [J].
Borish, LC ;
Nelson, HS ;
Corren, J ;
Bensch, G ;
Busse, WW ;
Whitmore, JB ;
Agosti, JM .
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2001, 107 (06) :963-970
[9]   Interleukin-4 receptor in moderate atopic asthma - A phase I/II randomized, placebo-controlled trial [J].
Borish, LC ;
Nelson, HS ;
Lanz, MJ ;
Claussen, L ;
Whitmore, JB ;
Agosti, JM ;
Garrison, L .
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 1999, 160 (06) :1816-1823
[10]  
Bousquet J, 2000, CLIN EXP ALLERGY, V30, P2