Emerging immune targets for the therapy of allergic asthma

被引：46

作者：

Corry, DB ^{[1
]}

机构：

[1] Baylor Coll Med, Dept Med, Houston, TX 77030 USA

[2] Baylor Coll Med, Dept Immunol, Houston, TX 77030 USA

[3] Baylor Coll Med, Biol Inflammat Ctr, Houston, TX 77030 USA

来源：

NATURE REVIEWS DRUG DISCOVERY | 2002年 / 1卷 / 01期

关键词：

D O I：

10.1038/nrd702

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Recent discoveries on the molecular and cellular basis of asthma have markedly altered our understanding of this common respiratory disorder. These insights have come during an unexplained period of rising disease incidence and severity and are now being applied to develop improved therapies. This review explores the latest advances in our understanding of the pathogenesis of allergic asthma, and provides insight into the expanding collaborations between research scientists, clinicians and the pharmaceutical industry in the race to control the asthma epidemic.

引用

收藏

页码：55 / 64

页数：10

相关论文

共 98 条

[31] Impaired Th2 subset development in the absence of CD4 [J].

Fowell, DJ ;

Magram, J ;

Turck, CW ;

Killeen, N ;

Locksley, RM .

IMMUNITY, 1997, 6 (05) :559-569

[32] Impaired NFATc translocation and failure of Th2 development in Itk-deficient CD4+ T cells [J].

Fowell, DJ ;

Shinkai, K ;

Liao, XC ;

Beebe, AM ;

Coffman, RL ;

Littman, DR ;

Locksley, RM .

IMMUNITY, 1999, 11 (04) :399-409

[33]

Grunewald SM, 1998, J IMMUNOL, V160, P4004

[34] Requirement for IL-13 independently of IL-4 in experimental asthma [J].

Grünig, G ;

Warnock, M ;

Wakil, AE ;

Venkayya, R ;

Brombacher, F ;

Rennick, DM ;

Sheppard, D ;

Mohrs, M ;

Donaldson, DD ;

Locksley, RM ;

Corry, DB .

SCIENCE, 1998, 282 (5397) :2261-2263

[35] Control of TH2 polarization by the chemokine monocyte chemoattractant protein-1 [J].

Gu, L ;

Tseng, S ;

Horner, RM ;

Tam, C ;

Loda, M ;

Rollins, BJ .

NATURE, 2000, 404 (6776) :407-411

[36]

Hartert T V, 2000, Curr Opin Pulm Med, V6, P4, DOI 10.1097/00063198-200001000-00002

[37] A Toll-like receptor recognizes bacterial DNA [J].

Hemmi, H ;

Takeuchi, O ;

Kawai, T ;

Kaisho, T ;

Sato, S ;

Sanjo, H ;

Matsumoto, M ;

Hoshino, K ;

Wagner, H ;

Takeda, K ;

Akira, S .

NATURE, 2000, 408 (6813) :740-745

[38] Soluble IL-4 receptor inhibits airway inflammation following allergen challenge in a mouse model of asthma [J].

Henderson, WR ;

Chi, EY ;

Maliszewski, CR .

JOURNAL OF IMMUNOLOGY, 2000, 164 (02) :1086-1095

[39] Prostaglandin D2 selectively induces chemotaxis in T helper type 2 cells, eosinophils, and basophils via seven-transmembrane receptor CRTH2 [J].

Hirai, H ;

Tanaka, K ;

Yoshie, O ;

Ogawa, K ;

Kenmotsu, K ;

Takamori, Y ;

Ichimasa, M ;

Sugamura, K ;

Nakamura, M ;

Takano, S ;

Nagata, K .

JOURNAL OF EXPERIMENTAL MEDICINE, 2001, 193 (02) :255-261

[40] Differential effects of endogenous and exogenous interferon-γ on immunoglobulin E, cellular infiltration, and airway responsiveness in a murine model of allergic asthma [J].

Hofstra, CL ;

Van Ark, I ;

Hofman, C ;

Nijkamp, FP ;

Jardieu, PM ;

Van Oosterhout, AJM .

AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY, 1998, 19 (05) :826-835

← 1 2 3 4 5 6 7 8 9 10 →